Changes of serum CTGF and MMP-1 levels in patients with urinary incontinence after stroke during the rehabilitation course
YIN Ting
CHEN Haiping
ZHENG Wenjuan
YUAN Meihua
LEI Ran
CHEN Xiaoyin
Abstract：Objective To explore the changes in serum connective tissue growth factor(CTGF)and matrix metalloproteinase-1(MMP-1)levels in patients with urinary incontinence after stroke during the rehabilitation course and their relationship with treatment outcomes.Methods A total of 110 patients with urinary incontinence after stroke from May 2023 to June 2025 were selected as the study subjects(observation group),which were further divided into the effective treatment group(n=86)and the ineffective treatment group(n=24)based on treatment outcomes.Another 150 stroke patients without urinary incontinence were selected as the control group.Serum CTGF and MMP-1 levels were compared among the groups.The relationship between serum CTGF and MMP-1 levels and treatment outcomes in patients with urinary incontinence after stroke was explored by Spearman correlation analysis.The predictive value of serum CTGF and MMP-1 for treatment outcomes in patients with urinary incontinence after stroke were evaluated by the ROC curve.Results Serum CTGF and MMP-1 levels in the observation group were higher compared with control group(P<0.05).Serum CTGF and MMP-1 levels in both groups gradually decreased over time(P<0.05).At the same time points,serum CTGF and MMP-1 levels in the ineffective treatment group were higher than those in the effective treatment group after 2 weeks,4 weeks,and 6 weeks of treatment(P<0.05).Serum CTGF and MMP-1 levels in patients with urinary incontinence after stroke were negatively correlated with treatment outcomes after 2 weeks,4 weeks,and 6 weeks of treatment(P<0.05).The area under the curve(AUC)of serum CTGF and MMP-1 for predicting treatment outcomes in patients with urinary incontinence after stroke was 0.782 and 0.865 respectively(Z=7.910,8.116,both P<0.05),which was lower than that of the combined prediction(AUC=0.914).Conclusions Serum CTGF and MMP-1 levels decrease with the progress of the rehabilitation course in patients with urinary incontinence after stroke and can be used as important markers for predicting treatment outcomes.
Keywords：strokeurinary incontinenceconnective tissue growth factormatrix metalloproteinase-1treatment outcome
Publication Date：2026-02-28
Online Publishing Date：2026-03-13(First online date of this platform, not the publication date of the document)
Pages：5( 96-100 )