Serum SRC-3 and Netrin-4 levels in elderly patients with vascular cognitive impairment after ischemic cerebral infarction and their clinical significance
DOU Hailing
LI Shize
ZHAO Songyao
YANG Shuo
LI Jiajia
LÜ Huijun
ZHANG Yue
Abstract：Objective To explore the levels of serum steroid receptor coactivator 3(SRC-3)and axon guidance factor 4(Netrin-4)in elderly patients with vascular cognitive impairment(VCI)after ischemic cerebral infarction and their clinical significance.Methods A total of 102 elderly patients with VCI ischemic after cerebral infarction admitted to our hospital from November 2021 to December 2024 were selected as the VCI group,and another 102 elderly patients with ischemic cerebral infarction without VCI were selected as the non-VCI group.The differences in serum SRC-3 and Netrin-4 levels between the two groups were compared.The predictive value of serum SRC-3 and Netrin-4 for VCI after ischemic cerebral infarction in the elderly patients was analyzed by the ROC curve.The influencing factors of VCI after ischemic cerebral infarction in the elderly patients were investigated by multivariate logistic stepwise regression.Results The levels of serum SRC-3 and Netrin-4 in the VCI group were lower than those in the non-VCI group(P<0.05).ROC analysis showed that the area under the curve(AUC)of the combined(serial)prediction of serum SRC-3 and Netrin-4 for VCI after ischemic cerebral infarction in the elderly patients was 0.904,which was higher than the AUC of 0.761 and 0.815 for the individual predictions of serum SRC-3 and Netrin-4(Z=13.584,10.231,P<0.001).The VCI group had higher proportions of age,hypertension,diabetes,and multiple infarction foci,and lower MoCA scores than the non-VCI group(P<0.05).Multivariate analysis showed that advanced age,hypertension,diabetes,SRC-3≤0.53 ng/mL,and Netrin-4≤49.60 ng/mL were risk factors for VCI after ischemic cerebral infarction in the elderly patients(P<0.05).Conclusions Levels of serum SRC-3 and Netrin-4 in elderly patients with VCI after ischemic cerebral infarction will decrease,and the combined detection of the two factors has a good predictive value for VCI after cerebral infarction in the elderly patients.
Keywords：cerebral infarctionvascular cognitive impairmentsteroid receptor coactivator 3axon guidance factor 4elderly patients
Publication Date：2026-02-28
Online Publishing Date：2026-03-13(First online date of this platform, not the publication date of the document)
Pages：5( 67-71 )