Guidelines for diagnosis and treatment of central nervous system non-germinomatous germ cell tumors in Chinese children and adolescents(Version 2026)
PEDIATRIC NEUROSURGERY GROUP OF THE CHINESE SOCIETY OF NEUROSURGERY,CHINESE MEDICAL ASSOCIATION
MA Jie
CHEN Zhongping
ZHANG Rong
Abstract：Central nervous system germ cell tumors are common malignant tumors in children and adolescents.Pure germ cell tumors are significantly more sensitive to radiotherapy and chemotherapy than other types of germ cell tumors,so other types of germ cell tumors are collectively referred to as non-germinomatous germ cell tumors(NGGCT).The internationally recognized treatment method for central nervous system NGGCT is an integrated treatment approach combining surgery,chemotherapy,and radiotherapy.However,due to the diversity and complexity of its subtypes,treatment strategies also vary based on multiple related factors such as patient age,clinical symptoms,tumor marker expression,tumor location,tumor size,and pathological type.To standardize the diagnosis and treatment of central nervous system NGGCT,the Pediatric Neurosurgery Group of the Chinese Medical Association's Neurosurgery Branch has developed guidelines for the diagnosis and treatment of central nervous system NGGCT in Chinese children and adolescents based on domestic and international clinical research and experience.This guideline covers the integrated diagnosis and treatment plans for primary and recurrent central nervous system NGGCT in patients over 3 years old,hoping to further improve the treatment outcomes and prognosis of patients with central nervous system NGGCT in China.
Keywords：guidelinegerm cell tumorcentral nervous systemchildrennon-germinomatous germ cell tumorschemotherapyradiotherapysecond-look surgery
Publication Date：2026-02-28
Online Publishing Date：2026-03-13(First online date of this platform, not the publication date of the document)
Pages：8( 8-15 )