Deep cervical lymphatic-venous anastomosis for Alzheimer's disease:theoretical basis,therapeutic potential and future directions
HE Renke
XIE Shengqiang
CHENG Gang
ZHANG Jianning
Abstract：Alzheimer's disease(AD)is the most prevalent neurodegenerative dementia,clinically characterised by progressive episodic-memory decline that eventually encompasses multiple cognitive domains.Its neuropathological hallmarks are the extracellular deposition of β-amyloid(Aβ)in senile plaques and the intracellular accumulation of hyper-phosphorylated Tau protein in neurofibrillary tangles.With the aging acceleration of global population,the incidence of AD is steadily rising,imposing a substantial burden on public-health and healthcare systems.Breakthrough studies have recently highlighted the pivotal role of the meningeal lymphatic system in clearing cerebrospinal and interstitial metabolic waste,thereby influencing AD pathogenesis.Against this backdrop,deep cervical lymphatic-venous anastomosis(DLVA)has been proposed as a"clearance-end"surgical strategy that reconstructs brain-neck lymphatic outflow to expedite Aβ removal.This review synthesises the anatomical and surgical foundations of DLVA,collates current pre-clinical and clinical evidence,analyses its advantages and limitations,and outlines future research priorities—namely multicentral randomised controlled trials,precision imaging-guided planning,and multidisciplinary combination therapies—to provide a theoretical framework and technical roadmap for its clinical translation.
Keywords：Alzheimer's diseasedeep cervical lymphatic-vein anastomosissurgical treatment
Publication Date：2026-01-28
Online Publishing Date：2026-01-17(First online date of this platform, not the publication date of the document)
Pages：5( 109-113 )