Topological commonality of glioblastoma hypoxia and bacterial biofilm networks
LI Na
LIU Lulu
HUANG Shuting
CHEN Zhou
LI Mingkai
MAO Xinggang
XUE Xiaoyan
Abstract：Objective To analyze the existence of commonalities in the molecular interaction networks(MINWs)architecture between glioblastoma(GBM)hypoxia and bacterial biofilm.Methods Algebraic topology methods were used to analyze the topological invariants of the GBM-MINW and the Biofilm-MINW by comparing them with random networks.Results Both networks exhibited complex and stable non-random topological features:each contained a substantial number of high-dimensional simplices and maximal simplices,far exceeding those found in random networks.Persistent homology analysis further revealed highly stable topological characteristics in both networks,including cyclic and cavity structures with long life cycles.Conclusions The MINWs of glioblastoma hypoxia and bacterial biofilms share similar topological structures,both forming highly interconnected and stable high-dimensional architectures.This finding provides a cross-domain example for understanding universal principles governing complexity in living systems.
Keywords：glioblastomabiofilmsalgebraic topologynetwork analysis
Publication Date：2026-01-28
Online Publishing Date：2026-01-17(First online date of this platform, not the publication date of the document)
Pages：8( 6-13 )