Influencing factors for acute stress disorder after thrombolysis in young and middle-aged patients with first-onset acute cerebral infarction and construction of a risk prediction model
WEI Xiaoqing
WANG Yanhao
TIAN Xiaojia
TANG Zhixin
REN Wenju
YUAN Congcong
XING Weiwei
ZHANG Xueyan
Abstract：Objective To analyze the influencing factors of acute stress disorder(ASD)after thrombolysis in young and middle-aged patients with first-onset acute cerebral infarction(ACI)and to construct a risk prediction model.Methods Based on the occurrence of ASD,216 young and middle-aged patients with first onset ACI who received thrombolytic therapy at Baoding First Central Hospital from February 2020 to January 2025 were divided into ASD group(n=82)and non-ASD group(n=134).Pearson correlation analysis was used to explore the correlation between ASD and psychological resilience and self-perceived burden after thrombolysis in young and middle-aged patients with first-onset ACI.Multivariate logistic stepwise regression analysis was used to explore the influencing factors of ASD after thrombolysis in young and middle-aged patients with first-onset ACI.A nomogram model was constructed and its predictive value for ASD after thrombolysis in young and middle-aged patients with first-onset ACI was evaluated.Results ASD after thrombolysis in young and middle-aged patients with first-onset ACI was negatively correlated with psychological resilience and positively correlated with self-perceived burden(P<0.05).The age and National Institutes of Health Stroke Scale(NIHSS)score at admission in the ASD group were higher than those in the non-ASD group.The proportions of those with education level below high school,unemployed,monthly per capita family income<4000 RMB yuan,introverted personality,dysphagia,and hemiplegia in the ASD group were all higher than those in the non-ASD group(P<0.05).The risk factors of ASD in young and middle-aged patients with first-episode ACI after thrombolytic therapy were lower than high school education,introverted personality,hemiplegia and heavy burden of self-feeling,and good psychological resilience was the protective factor(P<0.05).The area under the curve(AUC)(95%CI)of the nomogram model for predicting ASD after thrombolysis in young and middle-aged patients with first-onset ACI was 0.904(0.852～0.956),with a specificity of 67.93%and a sensitivity of 92.37%.Conclusions The nomogram model constructed on ASD related factors in young and middle-aged first-onset ACI patients after thrombolysis has good predictive value and can be used to guide individualized risk assessment in clinical practice.
Keywords：acute cerebral infarctionyoung and middle-aged patientsthrombolytic therapyacute stress disorderinfluencing factorsnomogram
Publication Date：2025-12-28
Online Publishing Date：2025-12-02(First online date of this platform, not the publication date of the document)
Pages：5( 91-95 )