Advances of the treatment of exendin-4 on neurodegenerative diseases
SU Xiaohui
YU Fan
SONG Xinya
YANG Hao
ZHOU Jie
DING Xiaohan
Abstract：As an agonist for the glucagon-like peptide-1(GLP-1)receptor,exendin-4(Ex-4)primarily targets GLP-1 receptors in the pancreas and gastrointestinal tract.Ex-4 is essential in the treatment of type 2 diabetes.It has been reported that Ex-4 can cross the blood-brain barrier and act on GLP-1 receptors in the brain,exerting neuroprotective effects through various mechanisms.However,the efficacy of the drug in relation to the stage of the disease,as well as the safety issues of long-term use still need to be further verified.Nevertheless,the potential of this drug in the treatment of neurodegenerative diseases is still under scrutiny.The present review highlights the latest advancements in the use of exendin-4 for treating age-related neurodegenerative diseases.
Keywords：exendin-4GLP-1 agonistagingneurodegenerative changesalzheimer's disease
Publication Date：2025-10-28
Online Publishing Date：2025-10-09(First online date of this platform, not the publication date of the document)
Pages：7( 180-186 )