Changes of serum miR-124,Hcy and Lp-PLA2 and disease severity in patients with cerebral infarction
LIU Yamei
LI Jing
SONG Jingyang
ZHENG Tinghua
GUO Zhaohong
Abstract：Objective To study the changes of serum microRNA-124(miR-124),homocysteine(Hcy)and lipoprotein-associated phospholipase A2(Lp-PLA2)in patients with cerebral infarction and analyze their relationship with disease severity.Methods The data of 156 patients with cerebral infarction(study group)in the Third Affiliated Hospital of Xinxiang Medical University were retrospectively analyzed,and 160 healthy people with physical examination were selected as control group.The severity of the condition was assessed using the National Institutes of Health Stroke Scale(NIHSS)score,and patients were divided into mild,moderate,and severe groups.The differences in serological indicators among different groups were compared.Spearman correlation analysis was conducted to analyze the relationship between serum miR-124,Hcy and Lp-PLA2 levels and the severity of cerebral infarction.According to the prognosis status within 1 year of follow-up,participants were stratified into good prognosis and poor prognosis groups,and the differences in clinical data and serum indicators were compared.Receiver operating characteristic(ROC)curve analysis was employed to assess the predictive value of miR-124,Hcy and Lp-PLA2 on prognosis.Results The levels of serum miR-124,Hcy and Lp-PLA2 in study group were higher than those in control group(P<0.05),and the above levels were lower in mild group than those in moderate and severe groups(P<0.05),and were lower in moderate group than those in severe group(P<0.05).Spearman correlation analysis showed that serum miR-124,Hcy and Lp-PLA2 were positively correlated with disease severity(P<0.05).The proportion of infarction size>20cm2,proportion of multi-vessel lesions,NIHSS score at admission and serum indicators in poor prognosis group were higher than those in good prognosis group(P<0.05).ROC curve analysis showed that the sensitivities of serum miR-124,Hcy,Lp-PLA2 alone and in combination in predicting the prognosis of patients with cerebral infarction were 69.56%,80.43%,80.43%and 91.30%,and the specificities were 70.91%,68.18%,70.91%and 65.45%,and the areas under the curves(ACUs)were 0.676,0.782,0.828 and 0.910 respectively,which indicated that the combination of miR-124,Hcy and Lp-PLA2 had higher predictive value on prognosis.Conclusions The levels of serum miR-124,Hcy and Lp-PLA2 in patients with cerebral infarction increase significantly with the aggravation of disease,and combination of the above three indicators can better predict the prognosis of patients.
Keywords：cerebral infarctionhomocysteinemicroRNA-124lipoprotein-associated phospholipase A2disease condition
Publication Date：2025-10-28
Online Publishing Date：2025-10-09(First online date of this platform, not the publication date of the document)
Pages：5( 81-85 )