The role and mechanisms of metabolic reprogramming in secondary injury following intracerebral hemorrhage
LI Xia
TIAN Zhicheng
Abstract：Secondary injury following intracerebral hemorrhage(ICH)is a critical factor leading to neurological deterioration.Elucidating its underlying mechanisms holds great significance for enhancing the overall treatment of ICH.Research has demonstrated that the disruption of the local microenvironment post-ICH can induce the dynamic reprogramming such as cholesterol,iron,amino acids,sugar,and lipids in a variety of cells,including neurons,glial cells,and immune cells,which is also known as metabolic reprogramming.Such metabolic reprogramming can lead to pathological processes such as neuroinflammation,erythrolysis,cytotoxicity,oxidative stress,iron deposition,brain edema,and blood-brain barrier disruption,each characterized by distinct spatiotemporal features.An increasing number of studies are now concentrating on the characteristics,roles,and mechanisms of metabolic reprogramming in secondary neural injury after ICH.This review aims to systematically summarize the current research progress both domestically and internationally regarding the role and molecular mechanisms of metabolic reprogramming in secondary neural injury post-ICH,thereby providing novel insights and directions for the development of precise therapeutic strategies targeting secondary neural injury after ICH.
Keywords：intracerebral hemorrhagemetabolic reprogrammingsecondary injury
Publication Date：2025-10-28
Online Publishing Date：2025-10-09(First online date of this platform, not the publication date of the document)
Pages：5( 1-5 )