Neuregulin-1:a new target for pyroptosis regulation in traumatic brain injury combined with seawater immersion?
YANG Yang
CHEN Li
XU Yongjun
WANG Shousen
Abstract：Traumatic brain injury combined with seawater immersion(TBI+SI)is a common disease in modern naval warfare and offshore operations,with a high fatality and disability rate.Due to the complexity of the injury mechanism,its clinical treatment remains a tricky problem.Pyroptosis induced by neuroinflammation is an important injury mechanism of TBI+SI,which exacerbates neuronal death and leads to poor prognosis of patients.Therefore,intervention against pyroptosis may be an effective treatment strategy.Based on various research results,this article proposes a hypothesis that nerve growth factor Nrg-1 can inhibit the TLR4/NF-κB/NLRP3 signaling pathway by activating its receptor ErbB,reducing neuroinflammatory reactions,and thereby inhibiting pyroptosis,and hence alleviating TBI+SI injury.If this hypothesis is proven,it can provide a new direction for clinical adjunctive therapy of TBI+SI and improve the prognosis of patients.
Keywords：Neuregulin-1Traumatic brain injurySeawater immersionCell pyroptosisHypothesis
Publication Date：2025-06-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 174-177 )