Research Progress and Applications of Gut Microbiota in Parkinson's Disease
Abstract：Parkinson's disease (PD) is a neurodegenerative disorder mainly affecting middle-aged and elderly populations, and its etiology remains incompletely understood. Recent studies have found that the occurrence and development of PD are closely related to gut microbiota. Dysbiosis of the gut microbiota may lead to intestinal inflammation, imbalance of metabolites, and neuroinflammation, thereby participating in the process of PD development. Methods to regulate the gut microbiota, such as probiotic supplementation, dietary intervention, and fecal microbiota transplantation, may provide more comprehensive treatment options and new therapeutic ideas for PD patients. At the same time, due to the heterogeneity of gut microbiota among different populations, the long-term stability and safety of gut microbiota regulation, especially fecal microbiota transplantation, require further research and validation through a large number of rigorous trials. This article reviews the mechanisms of gut microbiota in the development of PD and related clinical applications in recent years.
Keywords：Parkinson's diseasegut microbiotaprobioticsfecal microbiota transplantation
Publication Date：2025-06-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 160-164 )