Predictive significance of serum VILIP-1 and Cav-1 for the prognosis of patients with severe craniocerebral injury treated with early hyperbaric oxygen therapy

LIU Bing; HUO Huiyong; LIU Jiajia; LIU Chao; ZHANG Wenchao; LEI Jianhua; CHEN Mingchao

doi:10.3639/j.issn.1671-2897.2025.03.018

Abstract：Objective To explore the predictive value of serum visinin-like protein-1(VILIP-1)and caveolin-1(Cav-1)for the prognosis of patients with severe craniocerebral injury(SCI)treated with early hyperbaric oxygen therapy.Methods A total of 150 SCI patients who received early hyperbaric oxygen therapy from October 2021 to June 2024 were selected.After a 6-month follow-up,the prognosis of the patients was evaluated using the Glasgow Outcome Scale(GOS),and they were divided into a good group(109 patients,GOS score 4-5)and a poor group(41 patients,GOS score 1-3).The predictive value of serum VILIP-1 and Cav-1 for the prognosis of SCI patients treated with early hyperbaric oxygen therapy was evaluated using ROC.The influencing factors on the prognosis of SCI patients treated with early hyperbaric oxygen therapy were explored using multivariate Logistic stepwise regression analysis.Results The serum levels of VILIP-1 and Cav-1 in the poor group were higher than those in the good group(P<0.05).The area under the curve(AUC)(95%CI)of serum VILIP-1,Cav-1,and their combination for predicting the prognosis of SCI patients treated with early hyperbaric oxygen therapy were 0.856(0.803-0.909),0.744(0.692-0.796),and 0.904(0.852-0.956)respectively.The proportion of patients in the poor group with age≥60 years,hypertension,subarachnoid hemorrhage,disappearance of the cisterna magna,and midline shift≥5 mm was higher than that in the good group,and the C-reactive protein level was higher,the time from injury to admission was longer,and the GCS score and platelet count at admission were lower than those in the good group(P<0.05).Multivariate analysis showed that low GCS score at admission(OR=0.485,95%CI:0.343-0.685),subarachnoid hemorrhage(OR=1.891,95%CI:1.376-2.597),midline shift≥5 mm(OR=2.547,95%CI:1.691-3.837),high expression of VILIP-1(OR=3.028,95%CI:1.903-4.819),and high expression of Cav-1(OR=2.502,95%CI:1.664-3.761)were risk factors for poor prognosis in SCI patients treated with early hyperbaric oxygen therapy(P<0.05).Conclusions Elevated levels of serum VILIP-1 and Cav-1 are associated with poor prognosis in SCI patients treated with early hyperbaric oxygen therapy,and these two indicators can be used as important markers for prognosis predicting.