Vascular recanalization rate in patients with acute ischemic stroke after endovascular intervention and its relationship with VEGF,D-D and sST2

XIE Cantao; LI Ying; LU Jing; YANG Canhong; LYU Tianming

doi:10.3639/j.issn.1671-2897.2025.03.013

Abstract：Objective To investigate the vascular recanalization rate in patients with acute ischemic stroke(AIS)after endovascular intervention and its relationship with vascular endothelial growth factor(VEGF),D-dimer(D-D)and soluble growth stimulating gene 2 protein(sST2).Methods A total of 153 AIS patients admitted to the Department of Neurology at the Third Affiliated Hospital of Southern Medical University from April 2019 to June 2023 were selected as the study subjects.They were divided into failed vascular recanalization group(n=22)and successful vascular recanalization group(n=131)according to the situation of vascular recanalization after endovascular intervention.Serum VEGF,D-D and sST2 levels in the two groups before endovascular intervention were compared.Other clinical data were collected through electronic medical records and surgical records.Multivariate logistic regression analysis was used to explore the relationship between vascular recanalization and serum VEGF,D-D,and sST2 in AIS patients after endovascular intervention.The receiver operating characteristic(ROC)curves were plotted to analyze the predictive value of serum VEGF,D-D,and sST2 for vascular recanalization failure in AIS patients after endovascular intervention.Results The vascular recanalization rate in this study was 85.62%.VEGF level in the failed vascular recanalization group was lower than that in the successful vascular recanalization group,and the levels of D-D and sST2 were higher than those in the successful vascular recanalization group,with statistically significant differences(P<0.05).There was a statistically significant difference in the National Institutes of Health Stroke Scale(NIHSS)score at admission between the two groups(P<0.05).Multivariate logistic regression analysis showed that VEGF and D-D were factors influencing vascular recanalization in AIS patients after endovascular intervention.ROC curve analysis showed that the areas under the curve of serum VEGF and D-D for predicting vascular recanalization failure in AIS patients after endovascular intervention were 0.952 and 0.917.The area under the curve of VEGF was larger.When the cut-off value was 247.0 pg/ml,its sensitivity and specificity for predicting vascular recanalization failure were 95.45%and 87.79%.Conclusions There are significant differences in the levels of VEGF,D-D and sST2 between AIS patients with successful and failed vascular recanalization after endovascular intervention.Detecting VEGF and D-D levels in AIS patients as auxiliary indices may effectively help to predict their risk of vascular recanalization failure.