Relationship between the expression of MAGED2 and EMP2 and the prognosis of H3K27M-mutant diffuse midline glioma
HU Peng
MAO Jiaying
ZHAO Gan
CHEN Mengsi
XU Lijun
ZHANG Xisheng
Abstract：Objective To investigate the relationship between the expression of melanoma-associated antigen D2(MAGED2)and epithelial membrane protein 2(EMP2)and the prognosis of H3K27M-mutant diffuse midline glioma(DMG).Methods A retrospective analysis was conducted on the clinical data of 117 patients with H3K27M-mutant DMG who were admitted to the hospital from December 2021 to December 2023.The expressions of MAGED2 and EMP2 in tumor tissues and adjacent normal tissues were compared.Cox proportional hazards regression model was used for multivariate analysis and Kaplan-Meier survival curves were plotted.Log-rank test was used to analyze the relationship between the expressions of MAGED2 and EMP2 and the prognosis.Results The positive rates of MAGED2 and EMP2 in tumor tissues were higher than those in adjacent normal tissues(P<0.05).There were statistically significant differences in the positive rates of MAGED2 and EMP2 in terms of tumor location,WHO grading,and metastasis(P<0.05).All patients enrolled in the study were followed up for 3-36 months.Kaplan-Meier survival analysis showed that survival time of MAGED2 positive patients was shorter than that of negative ones(χ2=65.356,P=0.000),and survival time of EMP2 positive patients was shorter than that of negative ones(χ2=54.578,P=0.000).Univariate Cox regression analysis showed that WHO grading,metastasis,MAGED2 positivity,and EMP2 positivity were factors influencing progression-free survival of patients with H3K27M-mutant DMG(P<0.05).Multivariate Cox regression analysis showed that WHO grading,metastasis,MAGED2 positivity,and EMP2 positivity were independent risk factors for the prognosis of patients with 3K27M-mutant DMG.Conclusions MAGED2 and EMP2 are positive in H3K27M-mutant DMG and related to the patient's clinicopathological features.Moreover,MAGED2 positivity and EMP2 positivity indicate shorter survival time,and they can serve as potential biological markers for evaluating the prognosis of patients with H3K27M-mutant DMG.
Keywords：Diffuse midline gliomaH3K27M-mutantMelanoma-associated antigen D2Epithelial membrane protein 2Prognosis
Publication Date：2025-06-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 52-57 )