Incidence of enteral nutrition-related diarrhea in patients with severe craniocerebral injury and its influencing factors

GAO Xin; KONG Xiangrun; CHEN Yunxia; LIANG Qianqian; GAO Ziheng; WANG Guanyu; WANG Li

Abstract：Objective To explore the incidence and its influencing factors of enteral nutrition-related diarrhea in patients with severe craniocerebral injury,and to provide guidance for their enteral nutrition support.Methods A total of 104 patients with severe craniocerebral injury who received enteral nutrition in Henan Provincial People's Hospital from January 2020 to June 2024 were selected,and the incidence of enteral nutrition-related diarrhea was counted.The clinical data of all the included patients were collected,and the influencing factors of enteral nutrition-related diarrhea in patients with severe craniocerebral injury were analyzed.Results Enteral nutrition-related diarrhea occurred in 39 of the 104 patients with severe craniocerebral injury,and the incidence was 37.50%(39/104).The results of univariate analysis showed that compared with patients without enteral nutrition-related diarrhea,the APACHEⅡscore,the proportion of patients with hypoproteinemia,the proportion of patients with postoperative fasting time＞48 hours,and the proportion of patients with mechanical ventilation in patients with enteral nutrition-related diarrhea increased(P＜0.05).There were no significant differences in age,gender,BMI,GCS score,injury factors,injury types,enteral nutrition infusion methods,and types of enteral nutrition preparations between the two groups(P＞0.05).Multivariate analysis showed that increased APACHEⅡscore(OR=2.565,95%CI:1.422-4.627),hypoproteinemia(OR=2.149,95%CI:1.220-3.786),postoperative fasting time＞48h(OR=2.261,95%CI:1.201-4.259),mechanical ventilation(OR=2.071,95%CI:1.091-3.931)were risk factors for enteral nutrition-related diarrhea in patients with severe craniocerebral injury(P＜0.05).Conclusions The incidence of enteral nutrition-related diarrhea is higher in patients with severe craniocerebral injury.The increase of APACHEⅡscore,hypoproteinemia,fasting for more than 48 hours after surgery and mechanical ventilation are the main risk factors for enteral nutrition-related diarrhea in these patients.