Clinical efficacy and safety of ultra early,early and late treatment of hypertensive basal ganglia cerebral hemorrhage

WANG Hongjuan; ZHANG Yuanchun; PANG Lingyun; YUAN Haicheng; LIU Fengjuan; GAO Qiang

Abstract：Objective To compare and analyze the clinical efficacy and safety of ultra-early,early and late treatment of hypertensive basal ganglia intracerebral hemorrhage.Methods A total of 120 patients with hypertensive basal ganglia intracerebral hemorrhage admitted to Qingdao Central Hospital,University of Health and Rehabilitation Sciences from June 2019 to June 2024 were selected as the study subjects,and all of them underwent neuroendoscopic minimally invasive intracerebral hematoma removal.According to different surgical treatment periods,the patients were divided into ultra-early group(bleeding to operation time＜6 h,n=34),early group(bleeding to operation time 6-12 h,n=45)and late group(bleeding to operation time＞12 h,n=41).The clinical efficacy,quality of life and ability to live[SF-36 score,ADL score],serum indexes[C-reactive protein(CRP),B-type natriuretic peptide(BNP),neuron-specific enolase(NSE)]and prognosis[GOS]and complications of the 3 groups were compared and analyzed.Results The total effective rate of the early group was 97.78%,higher than that of the ultra-early group(82.35%)and the late group(78.05%)(P＜0.05).After treatment,SF-36 and ADL scores were increased in all three groups,and the early group was higher than the ultra-early group and the late group(P＜0.05).After treatment,CRP and BNP were all decreased in the three groups,with the early group lower than the ultra-early group and the late group;the NSE was increased in the three groups,with the ultra-early group and the late group higher than the early group(P＜0.05).The good prognosis rate of the early group was 95.56%,which was higher than that of the ultra-early group(67.65%)and the late group(65.85%)(P＜0.05).The total incidence of complications in the early group was 11.10%,which was lower than 55.88%in the ultra-early group and 48.78%in the late group(P＜0.05).Conclusions Surgical treatment in hypertensive basal ganglia intracerebral hemorrhage within 6～12h has better efficacy and safety,which can significantly improve not only the quality of life,life ability and serum index level of patients,but also the overall prognosis.