Latest advances in basic research of pituitary neuroendocrine tumors:from molecular mechanisms to clinical applications
WANG Yongfei
ZHANG Qilin
Abstract：Pituitary neuroendocrine tumors(PitNETs)are complex and heterogeneous neuroendocrine tumors,whose development and progression involve multiple molecular mechanisms and signaling pathways.In recent years,significant advances have been made in the research of PitNETs,thanks to the rapid development in molecular genetics technology,single-cell sequencing,and artificial intelligence.These technologies have unveiled the molecular heterogeneity of the tumors,key gene mutations,and the characteristics of the tumor microenvironment,laying the groundwork for precise classification and personalized treatment.In the field of treatment,endoscopic technology has driven the optimization of surgical strategies,while the exploration of targeted therapy and immunotherapy provides new hope for invasive PitNETs.This review focuses on the latest advances in PitNET research,including core molecular mechanisms,the role of the immune microenvironment,AI-assisted risk prediction,and the practice and prospects of novel therapeutic methods,providing a reference for the future development of precision medicine in PitNETs.
Keywords：Pituitary neuroendocrine tumors(PitNETs)Molecular geneticsArtificial intelligenceSurgeryImmunotherapy
Publication Date：2025-04-08
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1-6 )