Mechanisms and research progress of CAR-T cells in immunotherapy for brain gliomas
CHEN Yiran
ZHAO Yaning
WANG Yiming
REN Ziyang
ZHANG Shiyuan
HU Tao
Abstract：Brain gliomas,particularly glioblastoma,are highly aggressive and difficult-to-treat primary intracranial tumors characterized by high rates of recurrence and mortality. Traditional treatment modalities such as surgery,radiotherapy,and chemotherapy have limited efficacy;thus,the search for novel therapeutic strategies has become a major focus in current glioma research. Immunotherapy has garnered increasing attention in cancer treatment,and among these,Chimeric Antigen Receptor T cell immunotherapy has emerged as a promising new strategy demonstrating great potential. This article systematically explores the mechanisms of CAR-T cells in the treatment of brain gliomas,discusses the latest advancements and challenges,and envisions future directions for CAR-T cell therapy in glioma treatment.
Keywords：GliomasCAR-TImmunotherapy
Publication Date：2025-02-08
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 120-123 )