Expression of DIRAS3 in glioma and its prognostic value
DING Hui
CHEN Shengbo
YANG Liangwang
WU Ran
YE Fuyue
YANG Kun
Abstract：Objective To investigate the expression of DIRAS family GTPase 3(DIRAS3) in glioma and its prognostic value. Methods UALCAN,GEPIA 2.0,and HPA databases were used to evaluate and verify the expression of DIRAS3 in human astrocytes and glioma cells. Genes positively related to clinical prognostic value of DIRAS3 in TCGA-LGG&GBM were analyzed based on the cBioPortal database,and a Cluster containing DIRAS3 was selected for GO and KEGG analysis using the STRING database. The qRT-PCR and WB were used on DIRAS3 in GBM. Drug sensitivity was analyzed by the CADSP database. Results DIRAS3 expression was highly correlated with WHO grade,Isocitrate Dehydrogenase (IDH) status,1p/19q co-deletion status,age,and poor prognosis. In addition,DIRAS3 was involved in the positive regulation of cell movement,focal adhesion,vascular development,and transcriptional dysregulation in cancer,and was sensitive to multiple anti-tumor drugs. Conclusions As it has a carcinogenic effect in gliomas,DIRAS3 is a novel,prognostic relevant candidate gene which can serve as both a potential diagnostic marker and a promising therapeutic target for gliomas.
Keywords：GliomaDIRAS3Drug susceptibilityTargets for treatment
Publication Date：2025-02-08
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：8( 5-12 )