Application and prospects of Raman and terahertz spectroscopy in the diagnosis of glioma

XU Zhenliang; MU Ning; LAN Chuan; LI Fei; WANG Yuye; CHEN Tunan; FENG Hua

Abstract：Glioma is the most common primary intracranial tumor,with strong invasiveness and heterogeneity in its biological behavior.Glioma patients have a poor quality of life and a short survival time with a high probability of up to 90%recurrence rate in the original site.To reduce recurrence,glioma resection surgery needs to remove the tumor body as much as possible while protecting brain function and adopting early comprehensive treatment.Accurate intraoperative localization of glioma boundaries and molecular typing is a prerequisite for achieving this diagnostic and therapeutic goal.Currently,the most widely used pathological detection methods in clinical practice are time-consuming and rely largely on the subjective judgments of clinical and pathological physicians.Raman and terahertz spectroscopy can reflect the structure of biological macromolecules,and are widely used in the field of glioma diagnosis,and the complementarity of their technical characteristics can help neurosurgeons accurately locate the boundaries of gliomas during surgery while achieving rapid qualitative analysis to assist physicians in adopting appropriate treatment methods.This review mainly summarizes the recent research progress of Raman and terahertz technologies and their limitations in the treatment of gliomas,with a focus on their combined use and research value in the field of glioma diagnosis.Prospects of the combination of these two methods in the field of glioma treatment are also discussed.