Safety and efficacy of mr-guided focused ultrasound unilateral pallidothalamic tractotomy for akinetic-rigid Parkinson's disease
ZENG Zijing
ZHOU Jiayou
YIN Chunyu
LIN Jiaji
LIU Yunmo
LU Haoxuan
ZHANG Dekang
ZHANG Jianning
LOU Xin
Li Xuemei
PAN Longsheng
Abstract：Objective To investigate the safety and efficacy of MR-guided focused ultrasound(MRgFUS)unilateral pallidothalamic tractotomy(PTT)for akinetic-rigid Parkinson's disease(ARPD).Methods Fourteen patients with ARPD were included in the study and underwent unilateral tractotomy.Unified Parkinson's Disease Rating Scale(UPDRS)scores and imaging data were collected at baseline and at 1,3 months after tractotomy.The nonparametric tests were used for quantitative analysis,and correlation analysis was used for screening the factors affecting the efficacy.Results The UPDRS score of the 14 patients with ARPD decreased from baseline at 1 and 3 months after tractotomy(P<0.001),and the score was further decreased in on-medication state after tractotomy(P<0.001).Total improvement rate was related to time,improvement rate of levodopa challenge test,Hoehn-Yahr stage and number of adverse events(P<0.05).Adverse events were minor.Conclusions MRgFUS unilateral PTT for ARPD is safe and effective.
Keywords：Magnetic resonance-guided focused ultrasoundAkinetic-rigid Parkinson's diseasePallidothalamic tractTreatment effectSafety
Publication Date：2024-12-09
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 22-27 )