Research progress of immune checkpoint inhibitors in the treatment of neuroglioma
ZHU Tong
ZENG Guanghong
ZHOU Jie
Abstract：In recent years,novel immunotherapies targeting immune components of the tumor microenvironment have demonstrated great prospect in the clinical management of neoplasms.Immune checkpoint proteins are stimulant or inhibitory regulatory factors that play a key role in maintaining immune homeostasis and preventing the onset of autoimmunity.In cancer,inhibitory immune checkpoints are activated to promote immune escape of cancer cells.Suppression of immune checkpoints is effective in the treatment of a variety of cancers,and preclinical studies have proved that this therapy might provide a brand new therapeutic regimen for the treatment of glioma.This review introduces the function of several immune checkpoints with extremely promising application prospects in the glioma microenvironment and relevant clinical investigations,providing both theoretical ground and noval ideas for the treatment of neuroglioma based on combined as well as single application of immune checkpoint inhibitors.
Keywords：NeurogliomaImmunotherapyImmune checkpoint
Publication Date：2024-10-09
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 87-91 )