Mesenchymal stem cell-derived extracellular vesicles:a novel strategy for traumatic brain injury treatment
LIU Zhiyong
LONG Qianfa
GUO Shiwen
Abstract：Traumatic brain injury(TBI)is caused by external forces leading to changes or damage in the structure and function of the brain,often resulting in severe cognitive,motor,and emotional impairments,which impose a heavy burden on patients,families,and the society.Mesenchymal stem cells(MSCs),with their potential for self-renewal and multi-lineage differentiation,have attracted significant attention in the field of tissue repair and regenerative medicine.Studies have shown that the therapeutic effects of MSCs are mainly mediated by their derived extracellular vesicles(EVs).Mesenchymal stem cell-derived extracellular vesicles(MSC-EVs)possess the ability to penetrate the blood-brain barrier,regulate the immune system,and promote tissue repair,demonstrating great potential in the treatment of TBI.This review systematically summarizes the research progress of MSC-EVs in TBI treatment,focusing on the biological characteristics,mechanisms of action,and clinical application prospects of EVs,and also addressing the existing challenges and future research directions.MSC-EVs are expected to become a new strategy for the precise treatment of TBI,but their clinical translation still faces numerous challenges,requiring interdisciplinary collaboration to further advance both basic and clinical research.
Keywords：Traumatic brain injury(TBI)Mesenchymal stem cells(MSCs)Extracellular vesicles(EVs)NeuroprotectionTissue repair and regeneration
Publication Date：2024-10-09
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 76-79 )