Research progress of ADC drugs in the treatment of brain metastasis in breast cancer patients
WEN Xinxin
LI Nanlin
Abstract：The existence of blood-brain barrier makes it difficult for the drugs to act on the brain lesion of patients with breast cancer brain metastasis(BCBM).As radiotherapy and surgery are the main clinical treatments for BCBM,its prognosis is very poor.The unique targeted delivery mechanism makes antibody-drug conjugate(ADC)drugs have a better concentration and efficacy in the brain.This paper intends to give a review of the research progress of ADC drugs targeting HER-2 and TROP2 in the treatment of BCBM,believing that more and more excellent ADC drug design and optimal use(including combination with other drugs,radiotherapy,etc.)will enable BCBM patients obtain longer survival time and better quality of life.
Keywords：Breast cancerBrain metastasisAntibody-drug conjugate drugsBlood-brain barrier
Publication Date：2024-10-09
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 72-75 )