Pan-cancer analysis and identification of oncogene SPI1 and its prognostic value and immune function in glioma
AYINUER·YUSHAN
HANIKEZI·TUERXUN
WANG Weina
FAN Hai
REZIWANGULI·REXITI
ZHU Guohua
Abstract：Objective To investigate the prognostic value of SPI1 in glioma and its relationship with immunosuppression.Methods GEPIA2 database was used to evaluate the expression and prognostic value of SPI1 mRNA in TCGA tumors.The correlation between SPI1 and other mRNAs in GBM was analyzed based on cBioPortal database,and the top 200 genes with the most significant positive correlation with SPI1 were selected for GO and KEGG pathway analysis through Metascape database.ssGSEA algorithm was used to evaluate the Spearman correlation between SPI1 mRNA expression in TCGA-GBM and immunoinfiltrating cells.CAMOIP database was used to score immune cell infiltration.Results Highly expressed in glioma and correlated with prognosis,SPI1 is predicted to be involved in both macrophage activation and the positive regulation of immune responses.SPI1 is associated with infiltration of most immune cells,and the high expression of SPI1 promotes the polarization of macrophages.Conclusion SPI1 plays an important role in the infiltration of glioma immune cells,and represents a valuable prognostic biomarker of glioma,and is a potential therapeutic target for glioma patients.
Keywords：GlioblastomaSPI1 geneImmune infiltrationBiomarker
Publication Date：2024-06-09
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：9( 30-38 )