Effects of intravascular interventional embolization on expression levels of serum peptide,IL-6,SOD and Caspase-3 in patients with ruptured cerebral aneurysm
CAO Bi
LIU Zijun
ZHANG Hao
Abstract：Objective To investigate the effects of intravascular interventional embolization in the treatment of ruptured cerebral aneurysms.Methods Seventy-eight patients with ruptured cerebral aneurysms admitted to our hospital from April 2021 to April 2023 were selected and randomly divided into a study group(n=39)and a control group(n=39).The control group was treated with craniotomy with clamps in the surgery,while the study group was given intravascular interventional embolization.Perioperative indexes,incidence rates of complications,both preoperative and postoperative expression levels of serum peptide(CPP),superoxide dismutase(SOD),interleukin-6(IL-6)and cysteine protease-3(Caspase-3)were statistically compared between these two groups.Results The blood loss in the study group was less than that in the control group,and the operating time as well as the length of hospital stay were shorter than those in the control group(P<0.05).Seven days after the treatment,serum levels of IL-6,CPP and Caspase-3 in the study group were downregulated compared with those in the control group,while serum level of SOD was higher than that in the control group(P<0.05).Incidence rates of complications in the study and control group were 5.13%and 20.51%respectively,showing that the difference was significant(P<0.05).Conclusion Intravascular interventional embolization is remarkably effective in the treatment of patients with ruptured cerebral aneurysm as it can regulate expression levels of serum CPP,IL-6,SOD and Caspase-3 with desirable safety.
Keywords：Rupture of cerebral aneurysmInterventional embolizationNeurological functionCysteine protease-3Prognosis
Publication Date：2024-04-09
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 45-48 )