Strengthen the Study of the Global Nature of Molecular Networks in Gliomas
Abstract：Glioblastoma(GBM)is a class of diseases driven by multiple genetic and epigenetic changes,and a single or few molecular targets may not be sufficient to cure this type of tumor.In particular,many current studies have achieved good results in experimental studies,but it is difficult to obtain obvious curative effect in clinical treatment.This fully shows that the real tumor environment in the human body is a kind of disease driven by multiple factors,and it is difficult to reverse the malignant degree of tumors by targeting a single or a few targets.One of the most important of these factors is the diversity of gene expression.According to current research reports,there are a large number of abnormally expressed genes in GBM.Among these abnormal genes,is there a single or a few genes that can be used as therapeutic targets?The question remains a mystery.However,it is generally accepted that a large number of molecules interact with each other,forming a complex system of molecular interacting networks(MINW).The overall nature of this MINW will ultimately affect the progression and outcome of the tumor.In this paper,an inductive summary is made for readers.
Keywords：GlioblastomaImmunotherapyMolecular interaction networkProtein interactionAlgebraic topologyTopological structure
Publication Date：2024-04-09
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1-6 )