Application of etomidate target controlled infusion for intervened treatment of intracranial aneurysm operation

LI Yan; ZHANG Jiuxiang; LI Hui; BAI Xiaoguang

Abstract：Objective The application of etomidate target controlled infusion for intervened treatment of intracranial aneurysm operation was investigated.Methods A total of 70 cases of intracranial aneurysms which were performed the intervened surgery (American Society of Anesthesiologists Ⅰ ～ Ⅱ) were randomly assigned to etomidate group (Group E) and propofol group (Group P).Both two groups were anesthetized with etomidate and propofol target controlled infusion for induction and maintenance,respectively.The systolic pressure (SBP),diastolic pressure (DBP) and heart rate (HR) were determined before induction,before tracheal intubation,at 5 min after tracheal intubation,at the beginning of operation and after drug withdrawal.In addition,the operation time and extubation time were recorded.During the maintenance of anesthesia,the plasma target concentration of etomidate was measured.Results In Group P,the blood pressure before tracheal intubation,at 5 min after tracheal intubation,at the beginning of operation and after drug withdrawal were lower than those before induction (P ＜ 0.05),while the blood pressure was significantly decreased.In Group E,the blood pressure before tracheal intubation,at 5 min after tracheal intubation,at the beginning of operation and after drug withdrawal were lower than those before induction,but there was no significant difference (P ＞ 0.05).The blood pressure and heart rate before tracheal intubation,at 5 min after tracheal intubation,at the beginning of operation and after drug withdrawal in Group P were significantly decreased as compared to Group E (P ＜ 0.05).During maintenance of anesthesia,the plasma target concentration of etomidate was (0.25 ± 0.08) μg/mL.Conclusion Etomidate target controlled infusion can effectively reduce the circulation variation during anesthesia induction and maintenance in the intracranial aneurysm operation.It is a stable and reliable anesthesia method and the patient gets a rapid recovery after operation.