Clinical pathological analysis of neurohypophyseal granular cell tumor

LIU Weishuo; JIANG Jianwei; HUI Guozhen

Abstract：Objective The clinical and pathological features of granular cell tumor (GCT) of neurohypophysis were investigated to improve the diagnosis and differential diagnosis.Methods Three cases of neurohypophyseal GCTs were retrieved.Their clinicopathologic and immunohistochemical features were studied,and the related literature was also reviewed.Results Three patients included 1 male and 2 female patients aged from 41 to 66 years old.Histologically,the tumor was composed of round or polygonal cells with abundant granular eosinophilic cytoplasm.No necrosis and significant mitotic figures were identified.Immunohistochemically,the tumor cells showed strongly positive for S-100 (3/3),CD56 (2/3) and Vimentin (2/3),while weak or focal positive for glial fibrillary acidic protein (GFAP,1/3),and Ki-67 proliferation index was low (1％～ 5％).Its abundant cytoplasm contained granules positive for diastase-resistant periodic acid-schiff reaction.The follow-up showed that 3 cases survived.Conclusion Although extremely rare,the granular cell tumors of neurohypophysis have to be considered in the differential diagnosis of suprasellar masses to avoid the misleading interpretation and consequent wrong therapeutic management.