Clinical characteristics and epidemiology of intracranial tumor in childhood: a single center survey in northwest of China

YE Yuqin; HE Xiaosheng; YANG Yongxiang; SU Xinhong; KONG Chuiguang; BAI Wei; ZHANG Xin

Abstract：Objective The clinical characteristics and epidemiology of a single center children's intracranial tumor in northwest of China were analyzed.Methods During a 10-year period from January 2008 to December 2017,839 primary intracranial tumors in children were diagnosed histopathologically according to the latest WHO nervous system tumor classification and grade (2016).The distribution of tumor location,classification and grade,and the association with gender,age and source area were studied.Results A total of 839 children with intracranial tumors came from Shaanxi,Gansu,Ningxia,Qinghai and Xinjiang.In the series,supratentorial tumors accounted for 68.4％ and low grade tumor was 56.4％.The overall gender ratio (male to female) was 1.53 ∶ 1 and the age of onset was higher in 7 ～9 years old.The most frequent five tumors were astrocytic tumor (16.4％),craniopharyngioma (11.6％),medulloblastoma (9.3％),germ cell tumor (7.0％) and ependymal tumor (6.3％).The gender ratio (male to female) was 1.19∶1 and the grade ratio (low to high) was 2.61 ∶ 1.Conclusion This single center survey based on new WHO classification and grade reflects the clinical characteristics and epidemiology of intracranial tumors in northwest of China.