The long-term effect of biodegradable flow diverting stents on intracranial aneurysms of rabbit model
YAN Lubin
LU Peigang
WANG Kuizhong
HAO Zhenqiang
WANG Tianzhu
LIU Hui
Abstract：Objective The effect of two flow-diverting stents on the elastase-induced aneurysm of New Zealand rabbit models was followed up for a long term (≥6 months) to investigate the safety and efficiency of stents for the treatment of intracranial aneurysms.Methods Twelve New Zealand white rabbits with elastase-induced aneurysm were divided into the experimental and control groups with six in each.The rabbits in experimental group were implanted the biodegradable flow diverting stents (BFDS)across the necks of aneurysms and the abdominal aortas (AA) covering the ostium of a lumbar artery.The rabbits in control group were used the metal flow diverting stents (MFDS) instead.Both two groups were performed the digital subtraction angiography (DSA)at 6 months and 12 months after FDS implantation to evaluate the status of aneurysm embolization and the patency of side branches covered by FDS.Additionally,all rabbits were sacrificed by intravenous injection of excess sodium pentobarbital for pathology and the scan electron microscope (SEM).Results In the long-term follow-up,the complete aneurysm occlusion rates were better in the experimental group (100％,6/6) compared to the control group (20％,1/5) in virtue of DSA.SEM and the pathological results revealed neointima hyperplasia around the lumbar artery ostia,but it did not affect the blood flow into the lumbar artery.Conclusion The BFDS is effective for the treatment of aneurysms and is safe for normal perforating arteries covered in the long-term follow-up.
Keywords：Biodegradable flow-diverting stentsMetal flow diverting stentsAneurysmSide branchRabbitDigital subtraction angiography
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 100-104 )