Bidirectional injection of high-large dose urokinase for the treatment of severe ventricular hemorrhage

CHEN Shangjun; WANG Haiyan; ZUO Yi; ZHOU Xiaowei; XIAO Sanchao; QIAN Chao; XIE Guoqiang

Abstract：Objective The effects of urokinase injection for the treatment of ventricular hemorrhage were explored.Methods A total of 49 cases of ventricular hemorrhage patients were divided into control group and treatment group randomly.Both two groups used lateral ventricular puncture combined with bilateral ventricular drainage.Twenty-four cases of the treatment group were injected into 100 000 IU urokinase (UK) by the lateral ventricle drainage everyday,and then 100 000 IU UK drainage of lumbar cistern were performed after bilateral ventricular drainage.Twenty-five cases of the control group were injected into 20 000 IU UK by the lateral ventricle drainage everyday,and then 20 000 IU UK drainage of lumbar cistern were performed after bilateral ventricular drainage.Results The prognosis was evaluated according activities of daily living.In treatment group eight cases were Level Ⅰ,10 cases were Level Ⅱ,and 3 cases were Level Ⅲ with an efficient rate of 87.5％.While in control group,3 cases were Level Ⅰ,6 cases were Level Ⅱ,and 7 cases of Level Ⅰ with an efficient rate of 64.0％.The effect of the treatment group was much better than that of the control group (P ＜ 0.01).Conclusion By bidirectional injection of urokinase after minimally invasive surgery for the treatment of severe ventricular hemorrhage,large dose urokinase (UK) is safer and more reliable than the conventional dose.It not only can clear the intraventricular and subarachnoid hemorrhage,promote the awaking of patients,and significantly reduce the mortality and morbidity,but also reduce the intracranial infection,hydrocephalus,and cerebral infarction etc.