Expression of epidermal growth factor receptor gene affects the prognosis of post-operative radiation and chemotherapy of glioma patients
LI Jingyuan
XU Zaihua
SUN Jingchi
WANG Zhen
LIU Qiang
Abstract：Objective The effect of expression of epidermal growth factor receptor (EGFR) gene on the prognosis of post-operative radiation and chemotherapy in the patients with glioma and its significance were investigated.Methods A total of 196 cases of primary glioma with integrated data in the same medical teams of General Hospital of Shenyang Military Command were collected.The EGFR gene expression of different grades of glioma was counted and the post-operative 2-year survival rate with radiation and chemotherapy was compared.Results There were 139 cases of EGFR mutation including 0 case of Grade Ⅰ,62.6％ of Grade Ⅱ (33/53),68.33％ of Grade Ⅲ (41/60),and 87.83％ of Grade Ⅳ (65/74).The positive rate was increased with the increase of glioma maligancy.A total of 141 patients were followed up for 2 years and it suggested that radiation and chemotherapy could prolong the survival period.In the same pathological grade,the patients with positive EGFR expression had lower survival rate compared with those with negative expression.The higher expression rate,the lower the radiation sensitivity,the shorter the survival rate,and the survival difference was statistically significant.Conclusion Malignancy of glioma cells is closely related with the expression of EGFR,so EGFR gene can be used as an index to radiation and chemotherapy sensitivity.
Keywords：GliomaEGFRRadiotherapyChemotherapy
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 32-34 )