Expression of HMGB1 gene and its clinical significance in human glioma: a Meta-analysis

GUO Dan; SONG Jinning; HUANG Tingqin; ZHAO Junjie

Abstract：Objective The expression of high mobility group box-1 (HMGB1) and its clinical significance in human glioma were evaluated.Methods The literatures on HMGB1 and glioma were obtained by retrieving databases such as Pubmed,Embase,Ovid,Chinese National Knowledge Infrastructure (CNKI).Meta-analysis was conducted by Revman 5.3 software.Results Eventually 7 case-control studies were enrolled.HMGB1 expression in glioma group versus control group detected by immunohistochemistry (IHC) [Odds ratio (OR) =26.53;95 ％ confidence intervals (CI) =13.70 ～ 51.35;P ＜ 0.01] and realtime fluorescence quantitative polymerase chain reaction (RT-PCR) [mean difference(MD) =16.55;95％ CI =11.21 ～ 21.90;P ＜ 0.01],and HMGB1 expression in glioma pathological grade (OR =0.53;95％ CI =0.31 ～ 0.90;P =0.02) were all statistically significant.HMGB1 expression in glioma with epilepsy versus not with epilepsy was not significantly different (OR =5.32;95％ CI =0.10 ～ 293.11;P =0.41).Conclusion HMGB1 expression is significantly higher than that in the control group,and it is related to the pathological grade of glioma,suggesting that HMGB1 is expected to be used as an important reference for the diagnosis and prognosis of glioma.There is no difference in the expression of HMGB1 between glioma with epilepsy and not with epilepsy.