The expression and function of vascular endothelial growth factor receptor 3 in human glioblastoma
FU Peng
CEN Yongcun
HUANG Qin
ZHAO Hongyang
XIANG Wei
Abstract：Objective The expression of vascular endothelial growth factor receptor 3 (VEGFR-3) and its function in the process of proliferation,migration and tube-formation of human glioblastoma endothelial cells were explored.Methods The expression of vascular endothelial growth factor-C (VEGF-C) in human glioblastoma tissues and cell lines were detected by real-time polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA),while the expression of VEGFR-3 in human glioblastoma tissues and endothelial cells was studied by RT-PCR and immunohistochemistry.The effect of VEGFR-3 on the proliferation,migration and angioplasty of tumor vascular endothelial cells was investigated by blocking VEGFR-3 with special blocker MAZ51.Results VEGF-C could be found on glioblastoma tissues and cell lines.VEGFR-3 was expressed on glioblastoma tissues and endothelial cells,inhibition of VEGFR-3 could influence the proliferation,migration and tube formation ability of tumor vascular endothelial cells.Conclusion VEGFR-3 is involved in mimicry of human glioblastoma angiogenesis,which can be a new target of anti-angiogenesis therapy in human glioblastoma.
Keywords：VEGFR-3GlioblastomaEndothelial cellsVasculogenic mimcry
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 4-8 )