Clinical observation of different retention time after infusing of urokinase in the treatment of severe ventricular hemorrhage

GUO Jinguang; LI Haiyan; WANG Shaofei; YANG Hui; ZHANG Xiaojuan; LIN Xiaoyao

Abstract：Objective The effect of different retention time of urokinase on the treatment of severe ventricular hemorrhage after bilateral ventriculostomy was observed.Methods The clinical data of 70 patients with severe ventricular hemorrhage undergone bilateral ventriculostomy were retrospectively analyzed.These patients were divided into 3 groups according to the retention time of urokinase:Group A (23 patients) with retention time of urokinase for 1 h,Group B (25 patients) for 2 h,Group C (22 patients) for 3 h.The number of patients with complete hematoma dissipation at different time,admission time,delayed hydrocephalusat within 3 months,prognosis after 6 months in each group were observed.Results The hematoma dissipation in three groups had significant difference (P ＜0.05).The hematoma dissipation between Group A and Group B,and between Group A and Group C had statistically significant differences (P ＜ 0.017).But there was no significant difference between Group B and Group C (P＞0.017).The admission time in three groups had statistically significant difference (P ＜0.05),and so had between Group A and Group B and between Group A and Group C (P ＜ 0.05),But there was no significant difference between Group B and Group C (P ＞ 0.05).The delayed hydrocephalus in three groups had significant difference (P ＜0.05),so had between Group A and Group B and between Group A and Group C (P ＜0.05).But there was no significant difference between Group B and Group C (P ＞0.05).The results of prognosis after 6 months in three groups had no significant difference (x2 =1.705,P＞0.05).Conclusion The retention time of urokinase for 2 h is more suitable for the patients with severe ventricular hemorrhage who undergo external drainage.