Survival analysis of atypical meningiomas

YIN Shangjiong; CAO Cangzhu; CHENG Yuefei; DU Xiuyu

Abstract：Objective The outcomes and prognostic factors of atypical meningiomas were discussed.Methods The clinical and follow-up data were analyzed retrospectively in 31 patients with histologically proven atypical meningiomas who received the operation.Univariate and multivariate analysis were performed between gender,age,tumor location,Kamofsky Performance Status (KPS),extent of resection,adjuvant radiology and survival time using Kaplan-Meier survival analysis and Cox proportional hazards models.Results Of 31 patients,15 were male and 16 were female with a mean survival of 123 months.The 3-year,5-year and 8-year overall survival (OS) were 89％,84％ and 72％,respectively.Of 29 patients with surgical gross-total resection,the mean survival time was 71 months with a median time of 52 months.3-year,5-year and 8-year recurrence-free survival (RFS) were 30％,51％ and 62％,respectively.Univariate analysis showed the surgical extent of resection (P =0.03) was significant associated with OS,and the resection extent and mnultiple surgeries was related with RFS.Surgical extent of resection had significant effect on OS and tumor location,multiple surgeries,surgical extent of resection,and pre-operative Karnofsky performance status scale were related with RFS analyzed by Cox proportional hazards models.Conclusion Surgical gross-total resection is the key means to prolong survival time of patients with atypical meningiomas.