Effects of physcion on expression of NSE and GFAP in rats with cerebral injury
LI Changdong
LI Zhiyun
Abstract：Objective Effects of physcion on expressions of neuron specific enolase (NSE) and glial fibrillary acidic protein (GFAP) after transplantation of human umbilical cord mesenchymal stem cells (hUC-MSCs) in rats with traumatic brain injury were studied.Methods A total of 40 clean Wistar rats (2～ 3 months,weighing 200 ～250 g) were divided randomly into control group (10 rats),TBI group (10 rats),hUC-MSCs group (10 rats),and hUC-MSCs transplantation + physcion group (10 rats).Expressions of NSE and GFAP were detected by immunohistochemical assay.Results Compared with TBI model group,the expressions of NSE and GFAP in hUC-MSCs group and hUC-MSCs transplantation + physcion group were significantly increased,with the hUC-MSCs transplantation + physcion group the most significant.Conclusion Physcion can induce the expression of NSE and GFAP by hUC-MSCs,and exert its protective effect on the neurons after TBI.
Keywords：hUC-MSCsTransplantationTraumatic brain injuryPhyscionNeurogenic differentiation
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 321-324 )