Endoscopic transsphenoidal microsurgery for pituitary adenomas affects the post-operational hormone: a Meta-analysis
XU Wenzhong
GUO Zhibo
LI Jianjun
DING Jian
Abstract：Objective The effect of transsphenoidal endoscopic microsurgery for pituitary adenoma on the growth hormone (GH),prolactin (PRL),and adrenocorticotropic hormone (ACTH) were discussed.Methods The literatures about endoscopic resection of pituitary adenoma by searching PubMed,Web of Science and Embase databases were collected and assessed and screened according to the literature inclusion and exclusion criteria.All the data in the literatures were extracted by two staff members and were analyzed using Stata 14.0 software.Results After screening hterature,eventually seven met the requirements of literature included,including 1080 patients.Meta-analysis results:GH [risk differences (RD) =0.18;95％ confidence intervals(CI):0.06 ～0.27];PRL (RD)=0.20;95％ CI:0.14～0.27);ACTH (RD =0.02;95％ CI:0.14 ～0.17).The difference of post-operative recovery rate of GH and PRL between small adenoma and large adenoma groups was statistically significant (P ＜0.01).Conclusion After endoscopic treatment of pituitary adenorna,there is no statistically significant difference in ACTH recovery rate between small and large adenomas.Recovery rate of GH and PRL in small adenomas is higher than that of large adenomas.
Keywords：Pituitary adenomaGrowth hormone (GH)Prolactin (PRL)Adrenocorticotropic hormone(ACTH)Meta-analysis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 244-248 )