The relationship between isocitrate dehydrogenase gene mutation and chemotherapy in gliomas: a preliminary study
HAN Song
LU Yu
DONG Tao
YU Chunyong
LI Xiaoming
PAN Dongsheng
FENG Sizhe
Abstract：Objective The relatiomhip between IDH1 R132H variation in 46 patients with glioma and the chemotherapy efiicacy was invesigated.Methods The real-time fluorescence quantitative PCR (MGB) method was used to detect the R132H mutation of IDH1 gene.At the same time,the prognosis of patients with chemotherapy was obtained by clinical follow-up.The prognosis of chemotherapy and survival analysis was compared between the patients with IDH1 R132H variation and the wild-type patients.Results Univariate analysis showed that the patients with secondary glioblastoma (sGBM) with IDH1 mutatiom had longer PFS and OS after chemotherapy (P ＜0.001);the patients younger than 50 years and with KPS scores ＞ 80 had longer PFS and OS (P ＜ 0.001).Multivariate analysis (COX regression analysis) showed that IDH1 gene mutation was positively correlated with PFS and OS (P＜0.001).Effective group of patients with IDH1 gene mutation and wild-type was 47.2％ and 10.0％,respectively.The difference between two groups was statistically significant (P ＜0.001).Survival analysis showed that TMZ patients with IDH1 gene mutations had longer PFS.Conclusion The results of this study show that IDH1 gene R132H mutation is a sensitive indicator of TMZ chemotherapy in patients with sGBM,which provides a new reference for subsequent treatment of sGBM.
Keywords：GliomaIDH1 mutationDiagnosisTreatment
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 212-216 )