Expression and significance of pp65 protein of human cytomegalovirus in gliomas
LI Pengqi
LI Bingqin
YAN Zhifeng
CHEN Xiaoyan
YUAN Liang
DONG Qiufeng
YANG Xin
LI Sanzhong
ZHEN Haining
FEI Zhou
Abstract：Objective The expression and significance of pp65 protein of human cytomegalovirus (HCMV) in gliomas were investigated.Methods The expression of pp65 protein of HCMV was detected by immunohistochemistry in 175 cases of human brain ghoma and 10 cases of normal human brain tissue,as well as the relationship between its expression and clinicopathological features of gliomas was futher analyzed.Results Expression of pp65 protein in gliomas was significantly higher than that in normal human brain tissues (Z =-4.338,P =0.000).Immunostaining intensity of pp65 protein in malignant ghomas was significantly higher than that in benign gliomas (Z =-0.960,P =0.037),while the immunostaining intensity of pp65 protein was not significantly associated with the pathological grade (r =0.096,P=0.208),as well as with the gender (r =0.138,P =0.069),age (r =0.016,P =0.837) and tumor site (r =-0.147,P =0.52) of ghoma patients.Conclusion HCMV infection and its protein pp65 expression may be associated with the tumorigenesis of human brain gliomas,however its exact oncogenous mechanism needs further study.
Keywords：Human cytomegalovirus (HCMV)Pp65GliomaImmunohistochemistry
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 202-206 )