Infection and expression of human cytomegalovirus in craniopharyngiomas and its significance
YAN Zhifeng
LI Sanzhong
DONG Qiufeng
CHEN Xiaoyan
LI Juan
HUO Junli
GAO Dakuan
ZHEN Haining
FEI Zhou
Abstract：Objective The infection and expression of human cytomegalovirus (HCMV) in craniopharyngioma tissues are detected to investigate the etiological relation between HCMV infection and craniopharyngioma formation . Methods Expressions of immediate early protein 1-72 (IE1-72) and phosphorylated glycoprotein 65 (pp65) antigens of HCMV were examined by immunohistochemistry method in 89 cases of craniopharyngioma and 10 cases of normal brain tissues.Results The positive rates of HCMV IE1-72 and pp65 expression were 77.5% and 84.3% in craniopharyngiomas, respectively, but not in normal brain tissues;there were significant differences in the positive expression rates of HCMV IE1-72 and pp65 antigen between craniopharyngiomas and normal brain tissues (P=0.000, P=0.000).The positive rates of IE1-72 in adamantinomatous type and papillary type of craniopharyngiomas were 83.6%and 67.6% respectively, while that of pp65 was 89.1% and 76.5%, respectively; although positive expression rates of IE1-72 and pp65 in adamantinomatous type were a little higher than that in papillary type , there was no significant difference for both two groups (P=0.135, P=0.197).Conclusion Both HCMV IE1-72 and pp65 are highly expressed in craniopharyngiomas, while no expression of them is found in normal brain tissues, which implies HCMV infection and expression may be associated with craniopharyngioma formation, and the related patho-genic mechanism need research further.
Keywords：Human cytomegalovirus (HCMV)CraniopharyngiomaImmunohistochemistryImmediate early protein 1-72 (IE1-72)Phosphorylated glycoprotein 65 (pp65)
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 148-151 )