Relationship between MR imaging features and pathologic changes in human supratentorial low grade gliomas with IDH mutation

ZHANG Jinsong; SHANG Lei; YE Jing; ZHANG Guangwen; ZHAO Yongbo; WANG Yangang

Abstract：Objective The imaging features and related pathological indicators between the Isocitrate dehydrogenase ( IDH ) mutation group and wild-type group in human superatentorial low grade gliomas are investigated.Methods A total of 82 cases of gliomas (WHO gradeⅡ) confirmed by surgery were involved, including 39 cases of IDH mutation and 43 cases of IDH wild type.Sixty-one cases of them were performed contrast enhanced MRI before operation.Degrees of tumors'enhancement including none, slight, medium and severe enhancement were recorded respectively and its relationship with pathological indicators such as proliferating cell nuclear antigen Ki-67 (Ki-67), cadherin CD34 (CD34) and 1p/19q co-deletion by SPSS 19.0 software was analyzed.Results Low grade gliomas with IDH mutation likely occurred in right frontal lobe and then right and left temporal lobe , while IDH wild type group likely occurred in left frontal lobe and then left and right temporal lobe .There was significant difference between two groups by Fisher's Exact Test(P<0.05).There were no significant differences in enhancement degree, Ki-67, CD34 and the short arm of chromosome 1 /the long arm of chromosome 19 (1p/19q) co-deletion between IDH mutation group and IDH wild type group (P>0.05).There was positive correlation between degree of enhancement and Ki-67 index (rs=0.288, P=0.020, Spearman rank correlation analysis).There were no significant differences between enhancement degree and CD34 or 1p/19q co-deletion.Conclusion Low grade glioma with IDH mutation have marked tendency to occur in right frontal lobe and then temporal lobe .There is no significant difference in enhancement degree between IDH mutation group and IDH wild type group in low grade gliomas .