Temozolomide combined with intensity modulated radiation therapy (IMRT) for post-operative local residual of glioblastoma:a clinical study
ZHAO Ying
DING Wenxiu
YIN Xiaoxiang
YE Hongxun
Abstract：Objective The efficacy and safety of Temozolomide plus intensity-modulated radiation therapy (IMRT) and IMRT alone in the treatment for post-operative local residual of glioblastoma.Methods A total of 36 patients with local residual of glioblastoma post-operatively were divided into observation group and control group randomly.In the observation group, intensity modulated radiation therapy ( IMRT ) was synchronized with temozolomide chemotherapy, while the control group with IMTR alone.Radiation method was the same in two groups. The side effects during tumor treatment were observed.All patients were followed up after treatment.The change of tumor size was observed and score of Karnofsky Performance status was used to evaluate the neurologic status.Results Both tumor volume reduction and the improvement of nerve function score in observation group were better than those of control group (P<0.05).There was significant difference in survival rate between two groups (P<0.05). Adverse reactions in two groups were slight, such as nausea, vomiting, headaches or bone marrow suppression, etc, and no important organ damage happened, which did no affect the treatment.Conclusion The curative effect of IMRT combined with temozolomide chemotherapy is better than IMRT alone, and the adverse reactions are tolerable.
Keywords：GlioblastomaIntensity-modulated radiation therapyTemozolomideChemotherapy
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 334-337 )