Expression of kainic receptor in rabbits with severe head trauma treated by controlled decompression:an experimental research

CAI Xianfeng; WANG Yuhai; HE Xinjun; CHEN Weiliang; CAI Sang; YANG Likun; CHEN Lei

Abstract：Objective The expressions of the kainic recepors ( GluR5 and GluR6 ) and the pathological changes of the brain tissues in rabbits with severe head trauma were compared between conventional decompression and controlled decompression groups to provide the experimental basis for the application of controlled decompression in clinical practices.Methods The animal model of rabbit with severe head trauma was established by epidural balloon compression method.New Zealand white rabbits were randomly divided into sham operation group, routine decompression group and controlled decompression group.The expressions of GluR5 and GluR6, HE staining of brain tissues, and the changes of skull CT 24 h post-operation were observed.Results At 24 h post-operation, the expression of GluR5 of controlled decompression group was significantly higher than that of conventional decompression group;the expression of GluR6 of conventional decompression group was obviously more than that of the controlled decompression group.HE staining of brain tissues of controlled decompression group was significantly better than that of conventional decompression group.ICP at 24 h post-operation in control pressure group was significantly lower than that of conventional decompression group.The incidence of cerebral infarction in the controlled decompression group (10.5%) was significantly lower than that of the conventional decompression group (35.2%).Conclusion Controlled decompression operation can effectively alleviate ischemia-reperfusion injury of brain tissues in rabbits with severe head trauma and reduce the post-operative complications, such as cerebral infarction, so it plays a protective role on brain tissues.