Effect of early life stress on hippocampal neurogenesis of male rats
XU Hongyu
YE Yuqin
HAO Yelu
SHI Fei
YUAN Guohao
JIANG Longfei
HE Xiaosheng
Abstract：Objective The effect of early life stress on hippocampal neurogenesis of male rats is discussed. Methods Rat pups were suffered from maternal deprivation (MD) for 3 h from postnatal day (PND) 2 to 14. Immunofluorescence for Ki67 was used to assess the proliferation, and doublecortin ( DCX) to assess the number of immature neurons.Results Rats from MD group had much more DCX+cells (P<0.001) but less Ki67+cells (P<0.05) than those from control group.Conclusion Maternal deprivation (3 h, from PND2 to PND14) alters hippocampus neurogenesis in male rats.
Keywords：Early life stressMaternal separationNeurogenesisHippocampusMale rats
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 225-228 )