OECs secreted protein SC1 promotes neuronal synaptogenesis
DUAN Da
JIANG Miao
YE Yuqin
GE Lite
HE Xiaosheng
CHEN Ping
LU Ming
Abstract：Objective The role of secreted protein SC1 in synaptogenesis after neural stem cells ( NSCs ) induced by olfactory ensheathing cells (OECs) is discussed.Methods Mouse NSCs line C17.2 was induced by mouse OECs conditioned medium, then the presynapses were labeled with primary antibody bassoon and the expression of bassoon was identified with Western blot.Results The synapse number and expression of bassoon in OECs group were significantly higher than those of RA group.After mouse SC1 recombinant protein added into retinoic acid (RA) group, the synapse number and the expression of bassoon were close to those of OECs group. Conclusion OECs secreted protein SC1 can promote synaptogenesis after C17.2 NSCs induced by OECs conditioned medium.
Keywords：Olfactory ensheathing cellsNeural stem cellsProtein SC1Synaptogenesis
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 204-207 )