Changes of brainstem-auditory evoked potential in rat model with brain injury by lateral head rotation
HE Xiaosheng
ZHANG Xiang
FEI Zhou
Abstract：Objective To study the change and mechanism of brainstem-auditory evoked potential (BAEP) in rat model with brain injury by lateral head rotation. Methods The model of brain injury by lateral head rotation was produced with 20 adult rats. The rats'BAEP was measured before rotation and at 6 h after rotation. The test electrode was placed at the left C2 on the head. The short click sound was given to the left ear and continual sheltering was sent to the right ear. One thousand test results were added and then averaged. The latent period, wave-to-wave interval and amplitude of all waves in BAEP were recorded.Results Compared with the BAEP before head rotation, the latent period of wave Ⅰ , Ⅴ and the wave-towave interval of Ⅰ～Ⅲ, Ⅲ～Ⅴ were apparently prolonged, and the amplitude of wave Ⅲ, Ⅴ was markedly reduced at 6 h after rotation; on the other hand, no significant difference was found in the latent period of wave Ⅰ , wave-to-wave interval of Ⅰ , Ⅴ and amplitude of wave Ⅰ . Conclusion Lateral head rotation leads to abnormal BAEP. It is related to the damage of special conductive pathways in brainstem. The diffusely-scattered axonal injury in brainstem is the pathological basis in this animal model by mechanic head rotation.
Keywords：Brain injuryBAEPDiffuse axonal injury (DAI)Lateral head rotationRat
Publication Date：2007-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 388-391 )