Change of the rotational behavior after implantation of microencapsulated PC12 cells in Parkinson's disease rats
LV Shengqing
ZHANG Kecheng
YANG Hui
HUANG Qilin
LIU Jun
WU Ming
Abstract：Objective To observe the change of the rotational behavior in Parkinson's disease (PD) rats after implantation of microencapsulated PC12 cells.Methods A new method of immunoisolation (microcapsulation) was utilized for encapsulation of dopamine-secreting PC12 cells, and the cells were implanted into the brains of PD rats. Then the change of apomorphine-induced rotational behavior of the PD rats was analyzed. Tyrosine hydroxylase (TH) antibody immunohistochemistry stains of the cells in the implanted area were also proceeded.Results The rotational behavior of the PD rats reduced significantly. The turns of preimplantation and postimplantation 3 months were 11.88±2.04 rpm and 3.46±1.01 rpm, respectively. The microcapsules in the brains of PD rats were intact and TH immunopositive PC12 cells could exist for 3 months postimplantation.Conclusion The rotational behavior of the PD rats can be ameliorated after implantation of microcapsulated PC12 cells.
Keywords：MicroencapsulationPC12 cellImplantationParkinson's diseaseRotational behavior
Publication Date：2006-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 410-413 )