Transcription and expression of CCND1 in human brain gliomas
Abstract：Objective To investigate the transcription and expression of CCND1 and its role in oncogenesis and progression of human brain gliomas.Methods The expression of CCND1 mRNA and cyclin D1 protein was detected by in situ hybridization and immunohistochemistry respectively in 8 normal brain cases and 52 glioma cases ranging from WHO grade Ⅰ to Ⅳ. Proliferation activity was determined by proliferating cell nuclear antigen (PCNA) immunohistochemical labeling. Results CCND1 was aberrantly transcripted and expressed in gliomas of each malignancy grade. Mean labeling indices (LI) and positive rates for CD1 protein and mRNA significantly increased with the grade of pathological malignancy. Moreover close positive correlations had been found between LI of CD1 and mRNA and that of PCNA.ConclusionCCND1 is overexpressed in human glioma with a tendency to increase with pathological malignancy. In addition, it is positively associated with the proliferation of glioma cells. This suggests that CCND1 may act as an important promotive factor in the oncogenesis and progression of gliomas.
Keywords：CCND1CD1Gene expressionGlioma
Publication Date：2004-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 315-318 )